About 3 results found for searched term "PE 22-28" (0.136 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M52727 | PE 22-28 | Potassium Channel |
| PE 22-28 is a TREK-1 inhibitor with IC50 value of 0.12 nM. | ||
| M11331 | UC2288 | Mdm2 |
| UC2288 is a novel p21 attenuator with cellular permeability and oral activity (relatively selective activity for P21), based on the structural synthesis of sorafenib. UC2288 down-regulated the expression of P21 mRNA and reduced the level of P21 protein independently of p53, and had little effect on the stability of P21 protein. UC2288 did not inhibit VEGFR2 and Raf kinases, even at 10 μM. | ||
| M30721 | Ralimetinib | p38 MAPK |
| LY2228820 | ||
| Ralimetinib (LY2228820) is a potent and selective, ATP-competitive inhibitor of p38 MAPK α/β, with IC50s of 5.3 and 3.2 nM, respectively. Ralimetinib (LY2228820) selectively inhibits phosphorylation of MK2 (Thr334), with no effect on phosphorylation of p38α MAPK, JNK, ERK1/2, c-Jun, ATF2, or c-Myc. | ||
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